RANKL-RANK/OPG MOLECULAR COMPLEX

RANKL-RANK/OPG MOLECULAR COMPLEX

A remodelação óssea é um processo fisiológico cíclico e contínuo , o que garante a conservação e a renovação da matriz óssea. Osteossíntese da matriz óssea é atingido pelos osteoblastos e coordenadas dentro desta máquina complexa de remodelação óssea com reabsorção da matriz óssea extracelular realizada por osteoclastos. O fenótipo, função e ontogênese dos osteoblastos e osteoclastos são essencialmente diferentes. Osteoblastos surgem de células da medula óssea estroma, e dos osteoclastos surgem células progenitoras hematopoéticas mielóides/ monócitos / macrófagos. Ambos os tipos de células têm um objectivo comum - a estrutura óssea. O desequilíbrio entre as atividades efetoras de osteoblastos e osteoclastos tem implicações clínicas associadas com a diminuição ou aumento da densidade mineral óssea em massa, osteoporose ou osteopenia respectivamente. Relatórios de 1977-1988 ofereceu novas explicações que mudaram a percepção sobre o metabolismo ósseo e abriu novas interpretações immunoclinical com perspectivas terapêuticas. O equilíbrio do complexo trimolecular composto de Osteoprotegerin (OPG), RANKL (osteoprotegerina-ligante) e RANK, que são fatores de controle através da modulação osteoclastogênese, regula a homeostase da remodelação óssea. Estas moléculas, OPG, RANK e RANKL, funcionam como receptores e ligantes e pertencem à superfamília do fator de necrose tumoral (TNF). Palavras-chave: remodelação óssea, metabolismo ósseo, complexo trimolecular - OPG / RANKL-RANK.

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RANKL/RANK/OPG E REMODELAÇÃO ÓSSEA